Glycosidase inhibitors and uses thereof

ABSTRACT

A locking arrangement secures together first and second panels. The arrangement includes locking tabs ( 54, 56, 58 ) projecting from an end edge ( 64 ) of the first panel ( 12 ) and locking slits ( 50   a,    50   b,    50   c ) in the second panel ( 28 ). Each locking slit is provided for receiving a respective one of the locking tabs. The locking tabs and the locking slits are engageable by relative sliding movement with each other. At least one of the locking tabs and locking slits is configured to secure the first and second panels in a first overlapping position while at least another one of the locking tabs and locking slits is configured to secure the first and second panels in a second overlapping position.

CROSS REFERENCE TO RELATED APPLICATIONS

This application claims the benefit of U.S. Provisional PatentApplication No. 61/735,176 filed Dec. 10, 2012, which is incorporatedherein by reference in its entirety.

FIELD OF THE INVENTION

The present invention relates to a locking arrangement for a locking twopanels of a carton together to a carton and a blank and a method ofsecuring a carton blank about a product, more specifically, but notexclusively to a locking arrangement having multiple locking positions.

BACKGROUND OF THE INVENTION

In the field of packaging it is often required to provide consumers witha package comprising multiple primary product containers, suchmulti-packs are desirable for shipping and distribution and for displayof promotional information. For cost and environmental considerations,such cartons or carriers need to be formed from as little material aspossible and cause as little wastage in the materials from which theyare formed as possible. Another consideration is the strength of thepackaging and its suitability for holding and transporting large weightsof articles.

It is desirable to lock a pair of panels forming a package about theprimary product containers; in particular it is desirable to ensure atight fit of the carton, such as but not limited to a wraparound stylecarton, about the primary product container or containers.

SUMMARY OF INVENTION

The present invention seeks to overcome or at least mitigate theproblems of the prior art.

According to a first aspect of the present invention there is provided alocking arrangement for securing together a pair of panels, thearrangement comprising locking tabs projecting from an end edge of afirst panel of the pair of panels and locking slits provided adjacent anend edge of the second panel of the pair of panels, wherein a lockingslit is provided for receiving each of the respective locking tabs, thelocking tabs and the locking slits being engageable by relative slidingmovement therebetween, wherein at least one of the locking tabs orlocking slits is configured to secure the pair of panels in a firstoverlapping position and at least one of the other the locking tabs orlocking slits is configured to secure the pair of panels in a secondoverlapping position.

Optionally, the locking arrangement comprises at least one furtherlocking tab or locking slit configured to secure the pair of panels inat least one further position having another degree of overlap.

Optionally, the second degree of overlap when the first and secondpanels are disposed in the second position is greater than the firstdegree of overlap when the first and second panels are disposed in thefirst position.

Optionally, at least one of locking tabs shares a common cutline with atleast one adjacent locking tab.

Optionally, the locking arrangement comprises a first group of lockingtabs.

Preferably, each of the locking tabs in the first group sharing a commoncutline with at least one adjacent locking tab in the first group.

Optionally, the locking arrangement comprises a second group of lockingtabs.

Preferably, each of the locking tabs in the second group sharing acommon cutline with at least one adjacent locking tab in the secondgroup.

Optionally, the locking tabs in the first group of locking tabs arespaced apart from the locking tabs in the second group of locking tabs.

Alternatively, one of the locking tabs in the first group of lockingtabs is spaced apart from one of the locking tabs in the second group oflocking tabs.

Optionally, the spacing between a locking tab in the first group oflocking tabs and an adjacent locking tab in the second group of lockingtabs is greater than the spacing between a pair of adjacent locking tabsforming part of either of the first or second groups.

In some embodiments an aperture is disposed between a pair or adjacentlocking tabs which share a common cutline, the aperture being struck inpart from the first panel and defining in part a recess in the edge ofthe first panel such that the edge of the first panel defined by therecess is inset from a leading edge of the first panel.

Preferably, the at least a first one of the locking tabs comprises anengaging edge spaced from the free end edge of the first panel by afirst distance.

Preferably, the at least a second one of the locking tabs comprises anengaging edge spaced from the free end edge of the first panel by asecond distance, the second distance being greater than the firstdistance.

Optionally, the engaging edge is a trailing edge of the locking tab.

Optionally, the at least a first one of the locking slits is spacedapart from the end edge of the second panel by a first distance.

Optionally, the at least a second one of the locking slits is spacedapart from the end edge of the second panel by a second distance, thesecond distance being greater than the first distance.

Optionally, the at least a first one of the locking slits comprises anabutment edge spaced from the free end edge of the second panel by afirst distance.

Optionally, the at least a second one of the locking slots comprises anabutment edge spaced from the free end edge of the second panel by asecond distance, the second distance being greater than the firstdistance.

Optionally, the abutment edge is a defined by the locking slit.

Optionally, the locking tabs are each coupled to the first panel by afold line for allowing the locking tabs to fold with respect to thefirst panel.

Optionally, at least one first fold line coupling at least one firstlocking tab is disposed at first distance with respect to an end edge ofthe first panel and at least one second fold line coupling at least onesecond locking tab is disposed at second distance with respect to an endedge of the first panel, the second distance being greater than thefirst distance.

Preferably, the at least a first one of the locking tabs projects fromthe end edge of the first panel by a first dimension.

Optionally, the at least a second one of the locking tabs projects fromthe end edge of the first panel by a second dimension, the seconddimension being greater than the first dimension.

According to a second aspect of the present invention there is provideda blank for forming a carton comprising a plurality of panels forforming a top panel base panel and opposing side walls interconnectingthe top and base panels, wherein one of the plurality of panels is acomposite panel comprising a first panel and a second panel, the blankcomprising a locking arrangement, the arrangement comprising lockingtabs projecting from an end edge of the first panel and locking slitsprovided adjacent an end edge of the second panel, wherein a lockingslit is provided for receiving each of the respective locking tabs, thelocking tabs and the locking slits being engageable by relative slidingmovement therebetween, wherein at least one of the locking tabs orlocking slits is configured to secure the first and second panels in afirst overlapping position and at least one of the other the lockingtabs or locking slits is configured to secure the first and secondpanels in a second overlapping position.

According to a third aspect of the present invention there is provided acarton comprising a plurality of panels including a top panel, a basepanel and opposing side walls interconnecting the top and base panels,wherein one of the plurality of panels is a composite panel comprising afirst panel and a second panel, the carton comprising a lockingarrangement, the arrangement comprising locking tabs projecting from anend edge of the first panel and locking slits provided adjacent an endedge of the second panel, wherein a locking slit is provided forreceiving each of the respective locking tabs, the locking tabs and thelocking slits being engageable by relative sliding movementtherebetween, wherein at least one of the locking tabs or locking slitsis configured to secure the first and second panels in a firstoverlapping position and at least one of the other the locking tabs orlocking slits is configured to secure the first and second panels in asecond overlapping position.

Optionally, the degree of overlap when the first and second panels aredisposed in the second position is greater than the degree of overlapwhen the first and second panels are disposed in the first position,such that the carton has a smaller internal volume in the secondposition.

According to a fourth aspect of the present invention there is provideda locking arrangement for securing together a pair of panels, the pairof panels comprising a first panel and a second panel, the arrangementcomprising at least one first locking tab projecting from an end edge ofthe first panel, at least one second locking tab projecting from an endedge of the first panel and at least one first locking slit providedadjacent an end edge of the second panel for receiving the at least onefirst locking tab and at least one second locking slit provided adjacentan end edge of the second panel for receiving the at least one firstlocking tab, wherein the at least one first locking tab and the at leastone first locking slit are configured to secure the first and secondpanels in a first overlapping position and at least one second lockingtab and at least one second locking slit are configured to secure thefirst and second panels in a second overlapping position.

According to a fifth aspect of the present invention there is provided amethod for securing together a pair of panels, the pair of panelscomprising a first panel and a second panel and including lockingarrangement comprising at least one first locking tab projecting from anend edge of the first panel, at least one second locking tab projectingfrom an end edge of the first panel and at least one first locking slitprovided adjacent an end edge of the second panel for receiving the atleast one first locking tab and at least one second locking slitprovided adjacent an end edge of the second panel for receiving the atleast one first locking tab, wherein the at least one first locking taband the at least one first locking slit are configured to secure thefirst and second panels in a first overlapping position and at least onesecond locking tab and at least one second locking slit are configuredto secure the first and second panels in a second overlapping position,the method comprising;

-   -   determining whether to secure the pair of panels in the first or        second overlapping position,    -   sliding the pair of panels with respect to one another so as to        engage the at least one first locking tab with the at least one        first locking slit so as to engage the pair of panels in the        first overlapping position, and    -   when securing the pair of panels in the second overlapping        position, further sliding the pair of panels with respect to one        another so as to engage the at least one second locking tab with        the at least one second locking slit so as to engage the pair of        panels in the second overlapping position.

According to a sixth aspect of the present invention there is provided acarton for packaging one or more articles, the carton comprising aplurality of panels including a top panel, a base panel and opposingside walls interconnecting the top and base panels, wherein one of theplurality of panels is a composite panel comprising a first panel and asecond panel, the carton comprising a locking arrangement, thearrangement comprising locking tabs projecting from an end edge of thefirst panel and locking slits provided adjacent an end edge of thesecond panel, wherein a locking slit is provided for receiving each ofthe respective locking tabs, the locking tabs and the locking slitsbeing engageable by relative sliding movement therebetween, wherein aportion of at least one of the locking tabs shares a common cutline orweakened line of severance with a portion of at least one adjacentlocking tab when the carton is in a blank form.

Preferably, the portion of the at least one of the locking tabs iscomplementary in shape to the portion of the at least one adjacentlocking tab. This gives the at least one of the locking tabs theappearance of being struck from, or interrupted by, a portion of the atleast one adjacent locking tab.

Within the scope of this application it is envisaged that the variousaspects, embodiments, examples, features and alternatives set out in thepreceding paragraphs, in the claims and/or in the following descriptionand drawings may be taken independently or in any combination thereof.For example, features described in connection with one embodiment areapplicable to all embodiments unless there is incompatibility offeatures.

BRIEF DESCRIPTION OF THE DRAWINGS

Exemplary embodiments of the invention will now be described withreference to the accompanying drawings, in which:

FIG. 1 is a plan view from above of a blank for forming a cartonaccording to a first embodiment of the invention;

FIG. 2 is a perspective view from above of a portion of a lockingmechanism according to the first embodiment of the invention in a stageof assembly;

FIG. 3 is a perspective view from above of a portion of a lockingmechanism according to the first embodiment of the invention in a laterstage of assembly;

FIG. 4A is a perspective view of a carton formed from the blank of FIG.1 in which a pair of panels is locked in a first overlapping position;

FIG. 4B is a perspective view of a carton formed from the blank of FIG.1 in which a pair of panels is locked in a second overlapping position;

FIG. 5 is a plan view from above of a blank for forming a cartonaccording to a second embodiment of the invention;

FIG. 6 is a plan view from above of a blank for forming a cartonaccording to a third embodiment of the invention;

FIG. 7 is a perspective view from above of a portion of a lockingmechanism according to the third embodiment of the invention in a stageof assembly;

FIG. 8 is a perspective view from above of a portion of a lockingmechanism according to the third embodiment of the invention in anassembled condition;

FIG. 9 a view from below of a portion of a locking mechanism accordingto the third embodiment of the invention in an assembled condition;

FIG. 10 is a plan view from above of a blank for forming a cartonaccording to a fourth embodiment of the invention;

FIG. 11 is a fragmentary plan view of a blank for forming a cartonaccording to a fifth embodiment of the invention; and

FIG. 12 is another fragmentary plan view of the blank of FIG. 11,showing a portion of the blank different from a portion shown by FIG.11.

DETAILED DESCRIPTION OF EXEMPLARY EMBODIMENTS OF THE PRESENT INVENTION

Detailed descriptions of specific embodiments of the package, blanks andcartons are disclosed herein. It will be understood that the disclosedembodiments are merely examples of the way in which certain aspects ofthe invention can be implemented and do not represent an exhaustive listof all of the ways the invention may be embodied. As used herein, theword “exemplary” is used expansively to refer to embodiments that serveas illustrations, specimens, models, or patterns. Indeed, it will beunderstood that the packages, blanks and cartons described herein may beembodied in various and alternative forms. The figures are notnecessarily to scale and some features may be exaggerated or minimisedto show details of particular components.

Well-known components, materials or methods are not necessarilydescribed in great detail in order to avoid obscuring the presentdisclosure. Any specific structural and functional details disclosedherein are not to be interpreted as limiting, but merely as a basis forthe claims and as a representative basis for teaching one skilled in theart to variously employ the invention.

Referring to FIG. 1 there is shown a plan view from above of a blank 10capable of forming a carton for packaging one or more primary products,such as, but not limited to, bottles or cans, hereinafter referred to asarticles.

In the embodiments detailed herein, the terms carton and carrier refer,for the non-limiting purpose of illustrating the various features of theinvention, to a container for engaging, carrying, and/or dispensingarticles, such as bottles. However, it is contemplated that theteachings of the invention can be applied to various containers, whichmay or may not be tapered and/or cylindrical. Other exemplary articlesinclude bottles (for example metallic, glass or plastics bottles), cans(for example aluminium cans), tins, pouches, packets and the like.

The blank is formed from a sheet of suitable substrate. It is to beunderstood that, as used herein, the term “suitable substrate” includesall manner of foldable sheet material such as paperboard, corrugatedboard, cardboard, plastic, combinations thereof, and the like. It shouldbe recognized that one or other numbers of blanks may be employed, forexample, to provide the carrier structure described in more detailbelow.

In the exemplary embodiment, the blank is configured to form a carton orcarrier for packaging an exemplary arrangement of exemplary articles.For example, the arrangement is a matrix including rows and columns suchas a 2×2 arrangement of articles. The blank can be alternativelyconfigured to form a carrier for packaging other articles and/ordifferent arrangements of articles.

Blank 10 comprises a linear series of panels 12, 14, 16, 18, 20, 22, 24,26, 28, 28 a hinged one to the next by a respective fold line 13, 15,17, 19, 21, 23, 25, 27. Blank 10 comprises a pair of end closurestructures 30 a, 30 b which partially close ends of the carton assembledform the blank 10. In other embodiments it is envisaged that the endclosure structures 30 a, 30 b may fully close the ends of the carton.

The blank 10 comprises a first base panel 12 hinged to a first bevelledpanel 14 by a fold line 13. First bevel panel 14 is hinged to a firstlower side panel 16 by a fold line 15. First lower side panel 16 ishinged to a first upper side panel 18 by a fold line 17. First upperside panel 18 is hinged to a top panel 20 by a fold line 19. Top panel21 is hinged to a second upper side panel 22 by a fold line 21. Secondupper side panel 22 is hinged to a second lower side panel 24 by a foldline 23. Second lower side panel 24 is hinged to a second bevel panel 26by a fold line 25. Second bevel panel 26 is hinged to a second basepanel 28 by a fold line 27. Second base panel 28 is hinged to a hingepanel 28 a by a fold line 52.

First end closure structure 30 a comprises a first top end closure panel32 a hinged to the top panel 20 by a fold line 31 a. A first web panel34 a is hinged to first top end closure panel 32 a along a first sideedge, by a fold line 33 a. A second web panel 36 a is hinged to firsttop end closure panel 32 a along a second side edge, by a fold line 35a. A first gusset panel 38 a interconnects first web panel 34 a to afirst anchor panel 42 a, first gusset panel 38 a is hinged to first webpanel 34 a by a fold line 39 a and to first anchor panel 42 a by a foldline 43 a. A second gusset panel 40 a interconnects second web panel 36a to a second anchor panel 44 a, second gusset panel 40 a is hinged tosecond web panel 36 a by a fold line 37 a and to second anchor panel 44a by a fold line 41 a. First anchor panel 42 a is hinged to first upperside panel 18 by a fold line 7 a. Second anchor panel 44 a is hinged tosecond upper side panel 22 by a fold line 9 a. An aperture A separatesthe first gusset panel 38 a from the first upper side panel 18 and thetop panel 20. An aperture A separates the second gusset panel 40 a fromthe second upper side panel 22 and the top panel 20.

Second end closure structure 30 b comprises a second top end closurepanel 32 b hinged to the top panel 20 by a fold line 31 b. A third webpanel 34 b is hinged to second top end closure panel 32 b along a firstside edge, by a fold line 33 b. A fourth web panel 36 b is hinged tosecond top end closure panel 32 b along a second side edge, by a foldline 35 b. A third gusset panel 38 b interconnects third web panel 34 bto a third anchor panel 42, third gusset panel 38 b is hinged to thirdweb panel 34 b by a fold line 39 b and to third anchor panel 42 b by afold line 43 b. A fourth gusset panel 40 b interconnects fourth webpanel 36 b to a fourth anchor panel 44 b, fourth gusset panel 40 b ishinged to fourth web panel 36 b by a fold line 37 b and to fourth anchorpanel 44 b by a fold line 41 b. Third anchor panel 42 b is hinged tofirst upper side panel 18 by a fold line 7 b. Fourth anchor panel 44 ais hinged to second upper side panel 22 by a fold line 9 b. An apertureA separates the third gusset panel 38 b from the first upper side panel18 and the top panel 20. An aperture A separates the fourth gusset panel40 b from the second upper side panel 22 and the top panel 20.

Blank 10 comprises a means for locking the first and second base panels12, 28 together. The locking mechanism 70 comprises a male M portion anda female portion F forming a first part of a complimentary lockingmechanism 70 and second part of a complimentary locking mechanism 70.

Referring now to FIGS. 1 to 3 the first part M of the complimentarylocking mechanism 70 comprises a male locking tab 54/54 a, 56/56 a,58/58 a which is coupled to the first base panel 12 along fold lines 55,57, 59 respectively. The male locking tabs 54/54 a, 56/56 a, 58/58 aproject outwardly, in the plane of the first base panel 12, from the endedge 16 thereof. The male locking tab 54/54 a, 56/56 a, 58/58 acomprises a main portion 54, 56, 58 and an integral anchoring tab 54 a,56 a, 58 a which is hinged to one side edge of the main portion 54, 56,58 along a fold line 61, 63, 65 respectively. The fold lines 61, 63, 65are substantially perpendicular to the end edge 16 of first base panel12. The trailing edge 66 of the anchoring tab is spaced from end edge 16and, in use, provides a locking edge for cooperation with an abutmentedge defined by a locking slit in second base panel 28. In alternativeembodiments the main portion 54, 56, 58 may formed to include a nosewhich projects beyond the foldable anchoring tab 54 a, 56 a, 58 a tolead insertion of the male locking tab 54/54 a, 56/56 a, 58/58 a in alocking slit of second base panel 28.

Second base panel 28 includes a locking slit 50 a, 50 b, 50 c in theform of a shallow “Y” which is struck from second base panel 28 along afold line 52 extending parallel to the end edge 11 of second base panel28. Thus, second base panel 28 has a foldable front edge strip or hingepanel 28 a. The slit 50 a, 50 b, 50 c is formed by a continuous cut linecomprising a first part extending along hinge panel 28 a towards the endedge of the second base panel 28 at an acute angle with respect to foldline 52; a return part extending back to meet fold line 52 at an acuteangle with respect thereto; and an leg part extending substantiallyperpendicularly to fold line 52 from the vertex between the first partand the return part. When front edge strip 32 is folded out of the planeof the blank the slit 50 a, 50 b, 50 c is opened and the first andreturn parts define a guide projection 49 a extending outwardly fromfold line 52.

The upright leg portion of the “Y” shaped cut allows the materialforming the hinged panel 28 a above the aperture created by folding thehinge panel 28 a to flex or bend when inserting the male locking tabs54/54 a, 56/56 a, 58/58 a.

In order to lock together first and second base panels 12 and 28, firstthe anchoring tabs 54 a, 56 a, 58 a are folded 180 degrees about foldlines 61, 63, 65 respectively into face contacting relationship with theunderside of the respective main portion 54, 56, 58. Also, the hingepanel 28 a is folded about fold line 52 out of the plane of the blank(FIG. 2) to open the slits 50 a, 50 b, 50 c. Once the anchoring tabs 54a, 56 a, 58 a have been folded thus, the maximum transverse dimension(corresponding to the maximum width of the main portions 54, 56, 58)from fold line 61, 63, 65 to the opposite edge of the respective malelocking tab 54/54 a, 56/56 a, 58/58 a is sized so that the male lockingtab 54/54 a, 56/56 a, 58/58 a can be slidingly engaged in a respectiveone of the locking slits 50 a, 50 b, 50 c. The locking tabs 54/54 a,56/56 a, 58/58 a may be an interference fit in the locking slits 50 a,50 b, 50 c. Hence, locking tabs 54/54 a, 56/56 a, 58/58 a can beinserted into the locking slits 50 a, 50 b, 50 c until the trailing edge66 of the anchoring tabs 54 a, 56 a, 58 a has moved past, that is tosay, cleared the abutment edge 68 of the locking slits 50 a, 50 b, 50 c.The natural resilience of the paperboard material then allows the foldedanchoring tabs 54 a, 56 a, 58 a automatically to spring back into a moreupright position unless otherwise constrained whereby the trailing edge66 at or adjacent fold line 61, 63, 65 is brought into a position inwhich it will abut against the abutment edge 68 when tension is appliedto the first and second base panels 12, 28 in opposition to the lockingdirection i.e. in a direction tending to move the panels apart. Thus,the abutting engagement between edge 66 and edge 68 of the locking slits50 a, 50 b, 50 c maintains the first and second base panels 12, 28locked together. The projection 49 a aids in the alignment of thelocking tabs 54/54 a, 56/56 a, 58/58 a into the slits 50 a, 50 b, 50 cduring locking.

In some circumstances, such as when the panels 12, 28 are base panels ofa carton and packed articles are disposed upon the interlocked panels12, 28, both the hinge panel 28 a of panel 28 and the anchoring tabs 54a, 56 a, 58 a may be flat, that is parallel to the plane of the panels12, 28. Nevertheless, the abutment between trailing edge 66 at oradjacent fold lines 61, 63, 65 and abutment edge 68 maintains the panelsinterlocked. Moreover, the double-ply thickness of material provided byboth the main portions 54, 56, 58 and anchoring tabs 54 a, 56 a, 58 a issufficient to prevent withdrawal of the locking tab 54/54 a, 56/56 a,58/58 a from the locking slits 50 a, 50 b, 50 c. It will be appreciatedthat in this locking configuration, the trailing edge 66 liessubstantially parallel to the abutment edge 68 to enhance the engagementbetween the panels.

Central locking tab 56/56 a which is disposed between locking tabs 54/54a, 58/58 a is configured to provide a tighter locking position than theouter locking tabs 54/54 a, 58/58 a. In which the degree of overlap ofthe first base panel 12 with the second base panel 28 is greater thanwhich is achieved by engaging the outer locking tabs 54/54 a, 58/58 a.This is achieved by offsetting the abutment edge 66 of the locking tab56/56 a from the abutment edges of the outer locking tabs 54/54 a, 58/58a. The abutment edge 66 of the locking tab 56/56 a is disposed in closerproximity to the edge 64 of first base panel 12 than the abutment edges66 of the outer locking tabs 54/54 a, 58/58 a; the abutment edge 66 ofthe locking tab 56/56 a is offset by a distance O from the abutmentedges 66 of the outer locking tabs 54/54 a, 58/58 a. The outer lockingtabs 54/54 a, 58/58 a extends from the edge 64 of first base panel 12 bya first dimension L1. The central locking tab 56/56 a extends from theedge 64 of first base panel 12 by a second dimension L2. The firstdimension L1 is greater than the second dimension L2. The staggered oroffset arrangement of the leading edges of the locking tabs 54/54 a,56/56 a, 58/58 a provides that only the outer locking tabs 54/54 a,58/58 a need to be aligned simultaneously, thereby simplifying assemblyof the carton 90. Alignment of the central locking tab 56/56 a with itsrespective locking slit 50 b is aided or facilitated by the offsetarrangement of the leading edges of the locking tabs 54/54 a, 56/56 a,58/58 a, since the central locking tab 56/56 a is constrained once theouter locking tabs 54/54 a, 56/56 a, 58/58 a have been inserted intotheir respective locking slits 50 a, 50 c.

In the illustrated embodiment the male locking tabs 54/54 a, 56/56 a,58/58 a are coupled to the first base panel 12 by a respective fold line55, 57, 59. In alternative embodiments the fold lines 55, 57, 59 may beomitted.

Optionally, the fold line 57 coupling the locking tab 56/56 a to thefirst base panel 12 is offset from the fold lines 55, 59 coupling theouter locking tabs 54/54 a, 58/58 a to the first base panel 12. The foldline 57 is disposed in closer proximity to, preferably co-linear with,the edge 64 of first base panel 12 than the fold lines 55, 59 of theouter locking tabs 54/54 a, 58/58 a. The outer locking tabs 54/54 a,58/58 a are coupled to a small projection extending from the first basepanel 12 in this way the leading edge of the outer locking tabs 54/54 a,58/58 a is disposed further from the free end edge of the first basepanel 12 than the leading edge of the central locking tab 56/56 a, theouter locking tabs 54/54 a, 58/58 a are thereby brought into contactwith the second base panel 228 and hinge panel 228 a before the centrallocking tab 56/56 a.

In this way when bringing the first base panel 212 and second base panel228 together the outer locking tabs 54/54 a, 58/58 a may contact thehinge panel 228 a and slide over the hinge panel 228 a until the outerlocking tabs 54/54 a, 58/58 a contact the projection 49 a to align theouter locking tabs 54/54 a, 58/58 a with the outer locking slits 50 a,50 c.

Turning to the construction of the carton 90 as illustrated in FIGS. 4Aand 4B, it is envisaged that the carton 90 can be formed by a series ofsequential folding operations in a straight line machine so that thecarton 90 is not required to be rotated or inverted to complete itsconstruction. The folding process is not limited to that described belowand may be altered according to particular manufacturing requirements.

The carton 90 is formed by wrapping the blank 110 about one or morearticles (not shown). The top panel 20 is disposed over a group ofarticles, the top end closure panels 32 a, 32 b are folded about theends of the article group by folding the anchor panel 42 a, 42 b, 44 a,44 b abut fold line 43 a, 43 b, 41 a, 41 b respectively so as to besubstantially in face contacting relationship with the first or secondupper side panel to which each anchor panel 42 a, 42 b, 44 a, 44 b ishinged. This automatically folds the top end closure panels 32 a, 32 band web panels 34 a, 34 b, 36 a, 36 b about the group of articles. Thefirst and second upper side panels 18, 22 are folded (along with thefirst and second lower side panels 16, 24, first and second bevel panels14, 26 and first and second base panel 12, 28) about fold lines 19, 21respectively to place the anchor panels 42 a, 42 b, 44 a, 44 b betweenthe group of article and the respective first or second upper side panel18, 22; thus anchoring the top end closure panels 32 a, 32 b inposition.

The first and second bevel panels 14, 26 when provided are folded aboutfold line 15, 25 respectively about the lower portion of the articlegroup. The first and second base panels 12, 28 are folded about the foldlines 13, 28 respectively so as to be disposed below the group ofarticles. The complimentary locking mechanisms 70 are employed asdescribed above to lock the first base panel 12 and second panel 28together. The first and second base panels 12, 28 may be locked ineither a first overlapping position, as shown in FIG. 4A, in which theouter locking tabs 54/54 a, 58/58 a are fully engaged or fully insertedwith the locking slits 50 a, 50 c or a second overlapping position, asshown in FIG. 4B, in which all locking tabs 54/54 a, 56/56 a, 58/58 aare fully engaged or fully inserted with the locking slits 50 a, 50 b,50 c depending upon the dimensions of the article group being packagedand/or the tightness of the carton about the group of articles required.

In the first position as illustrated in FIG. 4A the central locking tab56/56 a is maintained in a folded condition, such that the anchor tab 56a is substantially in face contacting relationship with main portion 56of the central locking tab 56/56 a. The anchor tabs 54 a, 58 a of eachof the endmost or outer locking tabs 54/54 a, 58/58 a have passedthrough the respective locking slit 50 a, 50 c and have partiallyunfolded, due to the inherent resilience of the material of the blank10, such the anchor tabs 54 a, 58 a are in locking engagement with thehinge panel 28 a.

The carton 90 in the first position or assembly configuration, as shownin FIG. 4A, comprises a composite base panel 12/28 formed from the firstand second base panels 12, 28, the composite base panel 12/28 has widthdimension W1 defined between the first bevel panel 14 and the secondbevel panel 26. The carton 90 in the second position or assemblyconfiguration, as shown in FIG. 4B, comprises a composite base panel12/28 formed from the first and second base panels 12, 28, the compositebase panel 12/28 has width dimension W2 defined between the first bevelpanel 14 and the second bevel panel 26. The width dimension W2 is lessthan the width dimension W1 such that the first second bevel panel 14 isdisposed closer to the second bevel panel 26 in the second position thanin the first position.

In the second position the degree of overlap of the first base panel 12with the second base panel 28 is greater than the degree of overlap ofthe first base panel 12 with the second base panel 28 when disposed inthe first position.

In the second position the anchor tab 56 a of the central locking tab56/56 a in addition to the anchor tabs 54 a, 58 a of each of the endmostor outer locking tabs 54/54 a, 58/58 a have passed through therespective locking slit 50 a, 50 b, 50 c and have partially unfolded,due to the inherent resilience of the material of the blank 10, such theanchor tabs 54 a, 56 a, 58 a are in locking engagement with the hingepanel 28 a.

In the first position trailing edge 66 of each of the outer locking tabs54/54 a, 58/58 a is in abutment with abutment edge 68 of the hinge panel28 a. The hinge panel 28 a prevents the anchor tab 56 a from unfoldingsince the hinge panel 28 a is disposed over the anchor tab 56 a of thelocking tab 56/56 a.

In the second position trailing edge 66 of the central locking tab 56/56a is in abutment with abutment edge 68 of the hinge panel 28 a. Theanchor tabs 54 a, 56 a, 58 a are all unfolded. The trailing edge 66 ofeach of the outer locking tabs 54/54 a, 58/58 a may be spaced apart fromthe abutment edge 68 of the hinge panel 28 a. The outer locking tabs54/54 a, 58/58 a each serve to stabilise the interlocking arrangement ofthe first and second base panels 12, 28.

Referring now to FIGS. 5 to 11, there is shown alternative embodimentsof the present invention. In the second, third, fourth and fifthillustrated embodiments, like numerals have, where possible, been usedto denote like parts, albeit with the addition of the prefix “100”,“200”, “300” or “400” to indicate that these features belong to thesecond, third, fourth or fifth embodiment. The alternative embodimentsshare many common features with the first embodiment and therefore onlythe differences from the embodiment illustrated in FIGS. 1 to 4 will bedescribed in any greater detail.

FIG. 5 illustrates a blank 110 for forming a carton according to asecond embodiment, blank 110 comprises four apertures A1 struck at leastin part from the top panel 120. Two of the apertures interrupt the foldline 121 between the top panel 120 and the second upper side panel 122.Apertures A1 may each receive a portion of a respective article such asa neck portion or upper portion.

The blank 110 comprises four complimentary locking mechanisms andinclude four male locking tabs 154, 156, 158, 160 and four locking slits150 a, 150 b, 150 c, 150 d. The four male locking tabs 154, 156, 158,160 are arranged in a linear series so as to be in close proximity withat least one adjacent male locking tabs 154, 156, 158, 160; The anchortab of locking tab 154 is shaped to be complimentary to an edge portionof the main portion of the adjacent locking tab 156, anchor tab oflocking tab 156 is shaped to be complimentary to an edge portion of themain portion of the adjacent locking tab 158, anchor tab of locking tab158 is shaped to be complimentary to an edge portion of the main portionof the adjacent locking tab 160. It will be appreciated that each malelocking tabs 154, 156, 158, 160 shares a common cutline or weakened lineof severance with at least one adjacent male locking tabs 154, 156, 158,160.

The locking slits 150 a, 150 b, 150 c, 150 d are arranged in a linearseries and interrupt the fold line 152 coupling the hinge panel 128 a tothe second base panel 28. The central pair of locking slits 150 b, 150 cis disposed in closer proximity to the fold line 127 between the secondbase panel 128 and the second bevel panel 126 than the locking slits 150a, 150 d at each end of the linear series. Each of the central pair oflocking slits 150 b, 150 c is offset by a distance O with respect to thelocking slits 150 a, 150 d at each end of the linear series. The centrallocking slits 150 b, 150 c are disposed at a first distance x from thefree end edge of the second base panel 128 and the endmost locking slits150 a, 150 d are disposed at a second distance y from the free end edgeof the second base panel 128; the second distance y is less than thefirst distance x.

Blank 110 comprises three apertures 155, 157, 159; first aperture 155 isdisposed between first locking tab 154 and second locking tab 156,second aperture 157 is disposed between second locking tab 156 and thirdlocking tab 158, and third aperture 159 is disposed between thirdlocking tab 158 and fourth locking tab 160. Each of the first, secondand third apertures 155, 157, 159 is struck in part from the first basepanel 112 such that a portion of the edge of the first base paneldefined by each of the first, second and third apertures 155, 157, 159is offset from a leading edge of the first base panel defined by foldlines hingedly connecting the male locking tabs 154, 156, 158, 160 tothe first base panel 112.

When the hinge panel 128 a is folded about the fold line 152 the offsetO between the central pair of locking slits and the endmost lockingslits places the endmost locking slits 150 a, 150 d in closer proximityto the fold line 127 between the second base panel 128 and the secondbevel panel 126 than the central pair of locking slits 150 b, 150 c.

The blank 110 can be formed into a carton which comprises two lockingpositions:

-   -   A first locking position in which the first and second base        panels 112, 128 are disposed in overlapping relationship, the        region of overlap defining a first overlapping area. In the        first locking or overlapping position the endmost locking tabs        154, 160 are each in locking engagement with respective endmost        locking slit 150 a, 150 d in which they are received. The        central locking tabs 156, 158 are not fully inserted into the        respective locking slit 150 b, 150 c such that the anchor tab of        each of the central locking tabs 156, 158 is maintained in a        folded relationship, with respect to the respective main portion        of the central locking tabs 156, 158 to which it is hinged, by        the hinge panel 128 a.    -   A second locking position in which all the locking tabs 154,        156, 158, 160 are fully inserted or engaged with the respective        locking slit 150 a, 150 b, 150 c, 150 d in which they are        received, the central locking tabs 156, 158 are each in locking        engagement (the trailing edge of the anchor tab is in abutment        with the abutment edge of the locking slit 150 b, 150 c) with        the central locking slits 150 b, 150 c and the trailing edge of        the anchor tab of each of the endmost pair of locking tabs 154,        160 is spaced apart from the abutment edge of the respective        locking slit 150 a, 150 d.

In an alternative embodiment the central pair of locking tabs 156, 158are spaced apart from one another, a first endmost locking tab 154 beingin contact with a first one of the central locking tabs 156, and asecond endmost locking tab 160 being in contact with a second one of thecentral locking tabs 158. In this way the locking tabs 154, 156, 158,160 are arranged in two distinct groups, wherein the groups are spacedapart from one another but the locking tabs 154, 156, 158, 160 in eachgroup are substantially in contact with one another when formed in theblank 110. It is envisaged that the locking slits 150 a, 150 b, 150 c,150 d will be arranged so as to receive a respective one of the lockingtabs 154, 156, 158, 160. In such arrangements it is envisaged that eachlocking tab or locking slit in a group may lock the first and secondbase panels 112, 128 in the same locking position or in differentlocking positions. In this way a first group of locking tabs and lockingslits may lock the first and second base panels 112, 128 in a firstposition and a second group of locking tabs and locking slits may lockthe first and second base panels 112, 128 in a second position.

Turning now to FIGS. 6 to 10 there is shown a blank 210 for forming acarton according to a third embodiment. Blank 210 comprises analternative locking mechanism, which includes a male locking member 280a, 280 b, 280 c

Blank 210 comprises three complementary locking devices. Blank 210comprises a first part F of a complementary locking device and a secondpart M of a complementary locking device.

First part F comprises a flap 228 a hingedly connected to a first panel228 by fold line 252, first panel 228 forms a second base panel of acarton.

Fold line 252 is interrupted by a cut lines or weakened lines ofseverance 250 a, 250 b, 250 c. Cut lines 250 a, 250 b, 250 c are atleast partially offset from fold line 252. In the illustrated embodimentthe cut lines 250 a, 250 b, 250 c are disposed or located within flap228 a, such that each defines in part a first projection 289 a, 289 b,289 c, which first projections 289 a, 289 b, 289 c are integrally formedwith the first panel 228.

Cut lines 250 a, 250 b, 250 c are stepped or tiered in shape; a centrallinear portion defines a leading edge of first projections 289 a, 289 b,289 c. First linear section defines a first tier. A second tier isdisposed on either side of the first tier. Second tier is defined byouter portions 287 a, 288 a of cutline 250 a and is disposed closer tofold line 252 than the first tier. The outer portions 287 a, 288 adefining the second tier are preferably disposed at an angle withrespect to the fold line 252 and with respect to the first tier; theouter edges of the outer portions 287 a, 288 a of cutline 250 a definingthe second tier being disposed closer to the fold line 252 than theinner edges of the outer portions 287 a, 288 a.

The portion of the cut lines 250 a, 250 b, 250 c defining the first tierdefine a recess or aperture A2 in flap 228 a in a folded condition,which recess or aperture A2 is arranged to receive a portion of thesecond part M of the complementary locking mechanism.

The second part M comprises a foldable tab 280 a, 280 b, 280 c hingedlyconnected to a second projection along a fold lines 282 a, 282 b, 282 crespectively. The second projections extend from a free edge of a secondpanel 212, which forms a first base panel of a carton. The fold line 282a, 282 b, 282 c are interrupted by a cut lines or weakened lines ofseverance; the cut lines are arcuate in shape and each forms a tab 284a, 284 b, 284 c which is struck from material forming a respective oneof the second projections. The tabs 284 a, 284 b, 284 c are integralwith respective ones of the foldable tabs 280 a, 280 b, 280 c. A freeend edge of each foldable tab 280 a, 280 b, 280 c opposing therespective fold lines 282 a, 282 b, 282 c is stepped or tiered in shape;an endmost, first, tier defines in part a tongue 292 a disposedcentrally within the tab 280 a. Tongue 292 a is sized and arranged to bereceived in the recess or aperture A2.

Outer portions define in part the second tier of the foldable tab 280 a,each outer portion having an engaging edge 299 a, 299 b respectively;the second tier is disposed in closer proximity to the fold line 282 athan the first tier.

The second tier forms shoulders on either side of the central tongue 292a.

Preferably, in the folded state, the tab 280 a overlaps with the secondpanel 212 by a distance Z, as illustrated in FIG. 7; the distance Z issufficiently large that tab 280 a cannot pass entirely through theaperture A2, even when the flap 228 a is coplanar with the first panel228.

Turning to the assembly of the complementary locking devices asillustrated in FIGS. 7 to 10, it is envisaged that the complementarylocking devices can be formed by a series of sequential foldingoperations in a straight line machine so that the carton is not requiredto be rotated or inverted to complete its construction. The foldingprocess is not limited to that described below and may be alteredaccording to particular manufacturing requirements.

FIG. 7 illustrates a stage of assembly of the complementary lockingdevices. The flap 228 a has been folded about fold line 252. The flap228 a is illustrated folded to be perpendicular to first panel 228. Inother embodiments the flap 228 a may be folded through an angle lessthan 90 degrees, or may be allowed to at least partially unfold (seeFIG. 8), so as to define an obtuse angle between flap 228 a and firstpanel 228. In folding the flap 228 a, an aperture A2 has been createdbetween the flap 228 a and the first panel 228.

Foldable tabs 280 a, 280 b, 280 c are folded about fold lines 282 a, 282b, 282 c, into substantially overlapping or overlying relationship withthe respective second projection and at least a portion of second panel212.

The first and second panels 228, 212 are moved with respect to oneanother as indicated by directional arrows D1, D2 and D3 so as to insertthe folded tabs 280 a, 280 b, 280 c into aperture A2. As illustrated inFIG. 9 the tab 280 a, in a folded condition, at least partially passesthrough the aperture A2. The tab 280 a engages with the aperture A2created by folding the flap 228 a. The tongue 292 a engages with anupper edge 291 a of the aperture A; upper edge 291 a defines at least inpart the recess in which the tongue 292 a is received. In this way theupper edge 291 a restricts the tab 280 a from unfolding. The engagingedges 299 a, 299 b of the outer portions of tab 280 a engage with theflap 228 a at locations disposed adjacent to the recess.

In the illustrated embodiment of FIG. 8, the flap 228 a has unfolded, atleast partially, about fold line 252, so as to define an obtuse anglebetween the flap 228 a and the first panel 228 a. Similarly, the tab 280a has partially unfolded about fold line 282 a.

Tongue 292 a of tab 280 a is received in the recess.

Shoulder portions 286 a, 285 a engage with those portions of flap 228 adisposed on either side of the recess and defined in part by cut lines250 a, 250 b, 250 c. Upward travel, unfolding, of the tabs 280 a, 280 b,280 c is limited by the flap 228 a.

Tab 284 a engages with first panel 228 limiting unfolding of foldabletab 280 a.

It will also be appreciated that tab 280 a in the folded condition istapered so that it is narrower in width towards the leading edge. Thisassists in aligning the tab 280 a with the aperture A2, since theleading edge is smaller in dimension than the aperture A2.

It will also be understood that if the tab 280 a is inserted entirelythrough aperture A2 inadvertently, then the first and second panels228,212 remain locked together since the tab 280 a, 280 b, 280 b cannotunfold into a flat condition by virtue of the arcuate tab 284 a, 284 b,284 c, which engages first panel 228 preventing unfolding.

FIG. 9 illustrates the first and second panels 228, 212 in a lockedcondition. The projection 289 a at least partially overlaps with secondpanel 212; the projection 289 a being disposed outermost. Thisoverlapping relationship is optional, but when provided increasessecurity by preventing or reducing folding of first panel 228 about foldline 252, thereby helping to maintain first and second panels 228, 212in a substantially co-planar, or at least substantially parallel,relationship with one another.

The blank 210 provides two locking positions:

-   -   a first locking position in which the endmost male locking tabs        280 a, 280 c are in locking engagement with the endmost (or        outer) locking slits 250 a, 250 c or apertures A2 and the of the        central foldable tab 280 b of the central male locking tab 280 b        is maintained in a folded relationship with respect to the        respective second projection to which the central foldable tab        280 b is hinged, the tongues 291 b of the central male locking        tabs 280 b is prevented from being received in the respective        recess of the flap 228 a, the shoulder portions 286 a, 285 a of        the central male locking tab 280 b has not passed through its        respective locking slit or aperture and as such the central male        locking tab 280 b is not in locking engagement with the flap 228        a;    -   a second locking position in which all the locking tabs 280 a,        280 b, 280 c are fully inserted into the respective locking        apertures A2 in which they are received, the central locking tab        280 b is in locking engagement (the tongue of the foldable tabs        280 b is received within the respective recess of the a first        part F of the complementary locking device defined in flap 228        a) and the shoulder portions 286 a, 285 a of the central male        locking tab 280 b has passed through its respective locking slit        or aperture such that the central male locking tab 280 b is in        locking engagement with the flap 228 a and wherein the endmost        foldable tabs 280 a, 280 c are further inserted into the        respective apertures A2 such that the engaging edges 299 a, 299        b of the outer portions of endmost foldable tabs 280 a, 280 c        are spaced apart from the flap 228 a, in some embodiments the        endmost foldable tabs 280 a, 280 c may pass through the        apertures A2 in their entirety, in this second position the        endmost foldable tabs 280 a, 280 c are substantially prevented        or restricted from unfolding or returning to the plane of the        second panel 212 by engagement of the tab 284 a, 284 c with the        first panel 228.

Referring now to FIG. 10 there is shown a blank 310 for forming a cartonaccording to a fourth embodiment. Blank 310 comprises an alternativelocking arrangement which includes comprises a first part M of acomplementary locking device and a second part F of a complementarylocking device.

In the embodiment of FIG. 10 the male locking tabs 354, 356, 358 have analternative shape and configuration. There are provided three malelocking tabs 354, 356, 358 arranged in a linear series disposed alongand extending from a free end edge of the first base panel 212. Theendmost male locking tabs 354, 358 comprise an arcuate leading edgewhich is optionally substantially hemispherical. The endmost malelocking tabs 354, 358 comprise a recess which defines a trailing edgefor abutment with the second part F of the complementary locking device.The recess in male locking tab 354 is on an opposing side of the malelocking tab 354 to the recess in male locking tab 358, preferably therecesses are both on outermost side edges of each of the male lockingtabs 354, 358, that is to say the recesses are disposed on the side edgeof the male locking tabs 354, 358 in closest proximity to the open endsof the tubular structure defined by the carton walls 312, 314, 316, 318,320, 322, 324, 326, 328. The central male locking tab 356 comprises anarcuate leading edge, which is optionally substantially hemispherical,and comprises a pair of recesses defined on opposing side edges thereof,the recesses each define a trailing edge for abutment with the secondpart F of the complementary locking device, in this way the central malelocking tab 356 has substantially mushroom shaped appearance.

The recesses struck from the central male locking tab 356 are smaller indimension than those struck from each of the endmost male locking tabs354, 358 in this way the trailing edges of the central male locking tab356 are in closer proximity to the free end edge of the first base panel312 than the trailing edges of the endmost male locking tabs 354, 358,in this way a carton formed from the blank 310 comprises two distinctlocking positions in which the degree of overlap between the first basepanel 312 and second base panel 328 can be adjusted so as to increase ordecrease the dimension of the tubular structure formed by the cartonwalls 312, 314, 316, 318, 320, 322, 324, 326, 328. In this way thecarton can be adjusted to ensure a tight fit of the carton about itscontents, whereby allowing for compensation in dimensional differencesof the carton contents.

FIGS. 11 and 12 illustrate a blank 450 for forming a carton according toa fifth embodiment. FIGS. 11 and 12 shows the area of a first base panel412 and the area of a second base panel 428 only. The other area of theblank 40 is identical to that of the blank 110 of the second embodiment.

Referring to FIG. 11, locking tabs 454, 456, 458, 460 are arranged infirst and second groups. The locking tabs 454, 456 in the first groupshare a common cutline 462 whereas the locking tabs 458, 460 in thesecond group share a common cutline 463. The locking tabs 454, 456 inthe first group are spaced apart from the locking tabs 458, 460 in thesecond group. More particularly, the locking tab 456 in the first groupis spaced apart from the locking tab 458 in the second group. Thespacing between the locking tab 456 and the locking tab 458 is greaterthan the spacing between the adjacent locking tabs 454, 456 of the firstgroup or that between the adjacent locking tabs 458, 460 of the secondgroup. An aperture 455 is defined between the locking tabs 454, 456which share the common cutline 462 while an aperture 459 is definedbetween the locking tabs 458, 460 which share the common cutline 463.Each aperture 455, 459 is struck in part from the first base panel 412and defines in part a recess along the end edge of the first base panel.

Referring to FIG. 12, locking slits 450 a, 450 b, 450 c, 450 d arearranged in two groups and substantially in a linear series. Theyinterrupt the fold line 452 which couples a hinge panel 428 a to thesecond base panel 428. The locking slit 450 b of the first group isspaced from the locking slit 450 c of the second group. The lockingslits 450 a, 450 b of the first group are spaced from one another. Thelocking slits 450 c, 450 d of the second group are spaced from oneanother similarly to the locking tabs 450 a, 450 b in terms of spacing.The spacing between the locking slits 450 b, 450 c is greater than thespacing between the locking slits in the first group or in the secondgroup. Each of the locking slits 450 b, 450 c is offset by a distance Owith respect to the locking slits 450 a, 450 d. The central lockingslits 450 b, 450 c are disposed at a first distance x from the free endedge of the second base panel 428 and the endmost locking slits 450 a,450 d are disposed at a second distance y from the free end edge of thesecond base panel 128. The second distance y is less than the firstdistance x.

It can be appreciated that various changes may be made within the scopeof the present invention, for example, the size and shape of the panelsand apertures may be adjusted to accommodate articles of differing sizeor shape. In other embodiments of the invention it is envisaged that thelocking arrangement may comprise more than two locking positions; inwhich further locking tabs and further locking slits respectively areprovided for providing further locking positions having greater orlesser degrees of overlap between the first and second base panels thanthe first and second position disclosed hereinabove, such embodimentsmay comprise three or more locking positions. In other embodiments itwill be appreciated that the locking arrangement may comprise aplurality of male locking tabs offset with respect to each other so asto provide different position of engagement and a plurality of femalelocking slits or apertures offset with respect to each other so as toprovide different position of engagement, in some embodiment the maletabs and female slits may be arranged to give progressively tighterpositions of engagement (increasing the degree of overlap between thefirst and second panels) or they may be arranged such that the offset ofthe male tabs functions in opposition to the offset of the female tabsso as to cancel one another out, in such an arrangement the carton willonly have one locking position but the respective locations at which themale and female portions engage with one another will be offset from oneanother. For example in one embodiment a locking arrangement is providedcomprising two locking tabs projecting from an end edge of a first paneland two locking slits provided adjacent an end edge of the second panel.A locking slit is provided for receiving each of the respective lockingtabs, the locking tabs and the locking slits being engageable byrelative sliding movement of the locking tabs into the locking slits. Afirst one of the locking tabs and a first one of the locking slits areconfigured to secure the pair of panels in an at least partiallyoverlapping relationship. A first point of engagement between the firstand second panels is defined by the position that the first locking tabsand the first locking slit engage one another, the first point ofengagement and is disposed at first location. A second one of thelocking tabs and a second one of the locking slits are also configuredto secure the pair of panels in an at least partially overlappingrelationship. A second point of engagement between the first and secondpanels is defined by the position that the second locking tabs and thesecond locking slit engage one another; the second point of engagementis at second location. The first location is spaced at a first distancefrom a free end edge the first or second panel and the second locationis spaced at a second distance from a free end edge the first or secondpanel the second distance being greater than the first distance. In thisway the first and second points of engagement are offset from oneanother with respect to an edge of the composite panel formed bysecuring the first and second panels together; when the lockingarrangement is employed in a wraparound style carton the first andsecond points of engagement are offset from one another with respect toa tubular axis of the carton.

It will be recognised that as used herein, directional references suchas “top”, “bottom”, “front”, “back”, “end”, “side”, “inner”, “outer”,“upper” and “lower” do not limit the respective panels to suchorientation, but merely serve to distinguish these panels from oneanother.

As used herein, the terms “hinged connection” and “fold line” refers toall manner of lines that define hinge features of the blank, facilitatefolding portions of the blank with respect to one another, or otherwiseindicate optimal panel folding locations for the blank. A fold line istypically a scored line, an embossed line, or a debossed line. Anyreference to hinged connection or fold line should not be construed asnecessarily referring to a single fold line only; indeed it is envisagedthat hinged connection can be formed from any one or more of thefollowing, a short slit, a frangible line or a fold line withoutdeparting from the scope of the invention.

As used herein, the term “severance line” refers to all manner of linesthat facilitate separating portions of the substrate from one another orthat indicate optimal separation locations. Severance lines may befrangible or otherwise weakened lines, tear lines, cut lines, or slits.

It should be understood that hinged connection, severance lines and foldlines can each include elements that are formed in the substrate of theblank including perforations, a line of perforations, a line of shortslits, a line of half-cuts, a single half-cut, a cut line, aninterrupted cut line, slits, scores, any combination thereof, and thelike. The elements can be dimensioned and arranged to provide thedesired functionality. For example, a line of perforations can bedimensioned or designed with degrees of weakness to define a fold lineand/or a severance line. The line of perforations can be designed tofacilitate folding and resist breaking, to facilitate folding andfacilitate breaking with more effort, or to facilitate breaking withlittle effort.

1. A compound of Formula (I)

or a pharmaceutically acceptable salt thereof, wherein; R¹ and R² areeach independently hydrogen, C1-6alkyl, C2-6alkenyl or C2-6alkynylwherein the alkyl, alkenyl or alkynyl are optionally substituted withone up to the maximum number of substituents with one or more of fluoro,—OH, or methyl; R³ and R⁴ are each independently hydrogen, or C1-6acyl;W is (1) —(CH₂)_(m)—C(R⁵R⁶)-* wherein m is 1-3, R⁵ and R⁶ are eachindependently hydrogen, C1-3alkyl, —OH, halo, or —CF₃, and the *represents the point of attachment to the tetrahydropyran ring; (2)—(CH₂)_(n)—CH═C(R⁷)-* wherein n is 0-3, R⁷ is hydrogen or —CF₃, andthe * represents the point of attachment to the tetrahydropyran ring;(3) —(CH₂)_(p)—S(O)₂—CH₂-* wherein p is 0-1, and the * represents thepoint of attachment to the tetrahydropyran ring; or (4)—(CH₂)_(q)—S—CH₂-* wherein q is 0-1 and the * represents the point ofattachment to the tetrahydropyran ring; and X is (1)

 wherein R⁸ is hydrogen or C1-3alkoxy, (2) —C(O)—O—R⁹ wherein R⁹ ishydrogen, C1-3alkyl, C1-3alkenyl or C1-3alkynyl; or (3) —C(O)—NR¹⁰R¹¹wherein R¹⁰ and R¹¹ are each independently hydrogen, C1-3 alkyl, C1-3alkenyl or C1-3 alkynyl.
 2. The compound according to claim 1 or apharmaceutically acceptable salt thereof, wherein R¹ and R² are eachhydrogen or methyl.
 3. The compound according to claim 1 or apharmaceutically acceptable salt thereof, wherein R³ and R⁴ arehydrogen.
 4. The compound according to claim 1 or a pharmaceuticallyacceptable salt thereof, wherein W is —(CH₂)_(m)—C(R⁵R⁶)-* wherein m is1-3, R⁵ and R⁶ are each independently hydrogen, C1-3alkyl, —OH, halo, or—CF₃, and the * represents the point of attachment to thetetrahydropyran ring.
 5. The compound according to claim 1 or apharmaceutically acceptable salt thereof, wherein W is—(CH₂)_(n)—CH═C(R⁷)-* wherein n is 0-3, R⁷ is hydrogen or —CF₃, andthe * represents the point of attachment to the tetrahydropyran ring. 6.The compound according to claim 1 or a pharmaceutically acceptable saltthereof wherein W is —(CH₂)_(p)—S(O)₂—CH₂-* , wherein p is 0-1 and the *represents the point of attachment to the tetrahydropyran ring, or W is—S—(CH₂)_(q)—S—CH₂-* , wherein q is 0-1 and the * represents the pointof attachment to the tetrahydropyran ring.
 7. The compound according toclaim 1 wherein X is:

 wherein R⁸ is hydrogen or C1-3alkoxy.
 8. The compound according toclaim 1 or a pharmaceutically acceptable salt thereof wherein X is—C(O)—O—R⁹ wherein R⁹ is hydrogen or C1-3alkyl.
 9. The compoundaccording to claim 1 or a pharmaceutically acceptable salt thereofwherein X is —C(O)—NR¹⁰R¹¹ wherein R¹⁰ and R¹¹ are each independentlyhydrogen or C1-3alkyl.
 10. The compound according to claim 1 or apharmaceutically acceptable salt thereof, wherein R¹ is hydrogen and R²is methyl, or R¹ is methyl and R² is hydrogen or R¹ and R² are methyl;R³ and R⁴ are hydrogen; W is —(CH₂)_(m)—C(R⁵R⁶)-* wherein m is 1-2, R⁵and R⁶ are each independently hydrogen, —OH, fluoro, or —CF₃, and the *represents the point of attachment to the tetrahydropyran ring; and X is

 wherein R⁸ is hydrogen or —OCH₃.
 11. The compound according to claim 1or a pharmaceutically acceptable salt thereof wherein R¹ is hydrogen andR² is methyl, or R¹ is methyl and R² is hydrogen, or R¹ and R² are bothmethyl; R³ and R⁴ are hydrogen; W is —(CH₂)_(m)—C(R⁵R⁶)-* wherein m is1-2, R⁵ and R⁶ are each independently hydrogen, —OH, fluoro, or —CF₃,and the * represents the point of attachment to the tetrahydropyranring; and X is —C(O)—O—R⁹ wherein R⁹ is hydrogen or C1-3alkyl.
 12. Thecompound according to claim 1 or a pharmaceutically acceptable saltthereof wherein R¹ is hydrogen and R² is methyl, or R¹ is methyl and R²is hydrogen, or R¹ and R² are both methyl; R³ and R⁴ are hydrogen; W is—(CH₂)_(m)—C(R⁵R⁶)-* wherein m is 0-3, R⁵ and R⁶ are each independentlyhydrogen, —OH, fluoro, or —CF₃, and the * represents the point ofattachment to the tetrahydropyran ring; and X is —C(O)—NR¹⁰R¹¹ whereinR¹⁰ and R¹¹ are each independently hydrogen or C1-3alkyl.
 13. Thecompound according to claim 1 or a pharmaceutically acceptable saltthereof wherein R¹ is hydrogen and R² is methyl, or R¹ is methyl and R²is hydrogen, or R¹ and R² are both methyl; W is —(CH₂)_(n)—CH═C(R⁷)-*wherein n is 0-1, R⁷ is hydrogen or —CF₃, and the * represents the pointof attachment to the tetrahydropyran ring; and X is (1)

 wherein R⁸ is hydrogen or C1-3alkoxy, or (2) —C(O)—O—R⁹ wherein R⁹ ishydrogen or C1-3alkyl.
 14. The compound according to claim 1 which isselected from the group consisting of:

or a pharmaceutically acceptable salt thereof.
 15. A compound of theFormula (II)

or a pharmaceutically acceptable salt thereof, wherein R¹² and R¹³ areeach independently hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl,wherein the alkyl, alkenyl and alkynyl are optionally substituted fromone up to the maximum number of substituents with one or more of fluoro,OH, or methyl; R¹⁴ and R¹⁵ are each hydrogen; Y is —CN, —CH₂—CN, —C≡CH,—CH₂Cl, —C(CH₃)═CH₂, —C(CF₃)═CH₂ or —(CH₂)₂NR¹⁶R¹⁷ wherein R¹⁶ and R¹⁷are each independently hydrogen or C1-3alkyl, —C(C1-3alkyl)₂-Cl, or—C(═CH₂)—C1-3alkyl, and wherein the C1-3alkyl, —C(C1-3alkyl)₂-Cl, or—C(═CH₂)—C1-3alkyl are optionally substituted from one up to the maximumnumber of substituents with fluoro.
 16. The compound according to claim15 or a pharmaceutically acceptable salt thereof, wherein R¹² ishydrogen and R¹³ is methyl or allyl, or R¹² is methyl or allyl and R¹³is hydrogen, or R¹² and R¹³ are both methyl.
 17. The compound accordingto claim 15 which is selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.
 18. A compound of theFormula (III)

or a pharmaceutically acceptable salt thereof wherein, R¹⁸ and R¹⁹ areeach independently hydrogen, C1-6alkyl, C2-6alkenyl, or C2-6alkynyl,wherein the alkyl, alkenyl and alkynyl are optionally substituted fromone up to the maximum number of substituents with one or more of fluoro,OH, or methyl. R²⁰ and R²¹ are each hydrogen; R²² is (1) C1-3alkyl, —OH,C1-3alkoxy, wherein the alkyl and alkoxy are optionally substituted fromone up to the maximum number of substituents with one or more of fluoro,—OH, or methyl; or (2) NR²³R²⁴, wherein R²³ is hydrogen or C1-C3alkylwherein the alkyl is optionally substituted from one up to the maximumnumber of substituents with one or more of fluoro, OH, or methyl, andR²⁴ is C1-3alkyl, C1-3alkoxy, or cyclopropyl, wherein the alkyl, alkoxyand cyclopropyl are optionally substituted from one up to the maximumnumber of substituents with one or more of fluoro, OH, or methyl. 19.The compound according to claim 18 which is selected from the groupconsisting of:

or a pharmaceutically acceptable salt thereof.
 20. A pharmaceuticalcomposition comprising the compound of claim 1 or a pharmaceuticallyacceptable salt thereof, and a pharmaceutically acceptable carrier. 21.A pharmaceutical composition comprising the compound of claim 15 or apharmaceutically acceptable salt thereof, and a pharmaceuticallyacceptable carrier.
 22. A pharmaceutical composition comprising thecompound of claim 18 or a pharmaceutically acceptable salt thereof. 23.A method for treating a disease or disorder selected from the groupconsisting of consisting of Alzheimer's disease and related tauopathies,Amyotrophic lateral sclerosis, glaucoma, schizophrenia, Huntington'sdisease, Parkinson's disease, Schizophrenia, Mild Cognitive Impairment(MCI), Neuropathy and cancer, the method comprising administering to asubject in need thereof a therapeutically effective amount of a compoundaccording to claim 1 or a pharmaceutically acceptable salt thereof. 24.A method for treating a disease or disorder selected from the groupconsisting of consisting of Alzheimer's disease and related tauopathies,Amyotrophic lateral sclerosis, glaucoma, schizophrenia, Huntington'sdisease, Parkinson's disease, Schizophrenia, Mild Cognitive Impairment(MCI), Neuropathy and cancer, the method comprising administering to asubject in need thereof a therapeutically effective amount of a compoundaccording to claim 15 or a pharmaceutically acceptable salt thereof. 25.A method for treating a disease or disorder selected from the groupconsisting of consisting of Alzheimer's disease and related tauopathies,Amyotrophic lateral sclerosis, glaucoma, schizophrenia, Huntington'sdisease, Parkinson's disease, Schizophrenia, Mild Cognitive Impairment(MCI), Neuropathy and cancer, the method comprising administering to asubject in need thereof a therapeutically effective amount of a compoundaccording to claim 18 or a pharmaceutically acceptable salt thereof.